R821 Tricolor Multichannel Fiber Photometry System
R821 Tricolor Multichannel Fiber Photometry System
R821 Tricolor Multichannel Fiber Photometry System
R821 Tricolor Multichannel Fiber Photometry System

R821 Tricolor Multichannel Fiber Photometry System

R821 tricolor multichannel fiber photometry system is compatible with optoelectronics equipment. It has different wavelengths of excited light, 410nm, 470nm or 560nm, of which 410 is used to acquire reference signal and eliminate noise. The system can record signal of green fluorescence indicator like GCaMP and dLight or neurotransmitter probe and red fluorescence indicator like RCaMP, jrGECO1a or neurotransmitter probe.

And also it can be applied to record the neural signal for 9 sites at the same time.

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Overview

The fiber photometry system records changes in the fluorescence intensity of neurons in a specific brain area to reflect neuronal population activity. In the study of neural circuits, the fiber photometry system can perform long-term stable monitoring of the neurons of freely moving animals, and explore the correlation between neural activity and animal behavior.

  • Main Applications:
    Ca2 + and neurotransmitter signal detection
    Study the function of neural circuits
    Explore the mechanisms of neurological diseases
    Develop new fluorescent sensor probe
    Experiment of optical principle
  • Advantages
    Three kinds of excitation light sources, that is 410nm、470nm and 560nm, are respectively used for excitation
    of reference, green fluorescence and red fluorescence;
    Support up to 9 channels, suitable for simultaneous experiment of multiple animals or multiple brain
    locations;
    Dual highly sensitive detectors enabling independent and sequential detection to avoid interference of
    fluorescence excitation and detection, acquiring more accurate signal;
    Professional acquisition and analysis softwares are flexible and easy to operate with data processing functions
    available. No matlab programming is required;
    Supports multiple acquisition modes including continuous acquisition, interval acquisition, acquisition upon
    trigger, delayed acquisition and timing acquisition;
    Live display of DeltaF/F acquisition to check scale of signal changes during acquisition;
    Customized adjustment of output signal parameter, easily trigger and control external excitation equipment
    to achieve closed-cycle control of excitation and recording;
    Compatible with optogenetics for recording and stimulation at the same site.

R821 Tricolor Multichannel Fiber Photometry System

Stable Data Acquisition
R821 Tricolor Multichannel Fiber Photometry System

Fluorescence Comparison

  • Successful Case
    Journal:Nature Neuroscience
    Demand of the Product:We recorded calcium dynamics in DG-projecting SuM neurons by fiber photometry. In vivo recordings were carried out in an
    open-top HC (21.6×17.8×12.7 cm3) or EE (45×25× 20 cm3) containing toys, colorful balls, domes or tunnels and food, for 10min.
    Cite Reference:Li, YD., Luo, YJ., Chen, ZK. et al. Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nat Neurosci 25, 630–645 (2022). https://doi.org/10.1038/s41593-022-01065-x
    R821 Tricolor Multichannel Fiber Photometry System
    Journal:Cell Stem Cell
    Demand of the Product:We performed fiber photometry to record calcium activity of CA3 and CA1 pyramidal neurons labeled with GCaMP6f upon chemogenetic activation of SuM-enhanced ABNs by intraperitoneal CNO injection.
    Cite Reference:Li YD, Luo YJ, Xie L, Tart DS, Sheehy RN, Zhang L, Coleman LG Jr, Chen X, Song J. Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease. Cell Stem Cell. 2023 Apr 6;30(4):415-432.e6. doi: 10.1016/j.stem.2023.02.006
    R821 Tricolor Multichannel Fiber Photometry System

Specifications

Wavelength of excitation light 410nm 470nm 560nm
Power Min 0 µW, Max ≥ 100 µW, adjustable with an accuracy of 0.1 µW
Number of channels 9
Frame rate of fluorescent sampling Max 250fps
Digital signal interface 4 Input and 4 Output
Signal output Output frequency 0-500Hz, adjustable output pulse width and duration
Marking Manual marking (10), automatic marking (4), ROI marking (9)
Behavior camera 1920*1080(30fps) 1280*720(60fps) . Switchable among multiple frame rates of resolution
Compatible Compatible with optogenetics for recording and stimulation at the same site

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