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High-Impact Papers with RWD Drug Delivery Cannula

   |  May 24, 2024

What is drug delivery cannula?

Drug delivery cannula, also known as the implantation cannula of stereotaxic localization of brain or embedded cannula in brain, is designed to stereotaxically implant the customized guide cannula in the targeted brain region. The cannula’s various specifications are suitable for unilateral or bilateral drug delivery. One implantation can achieve multiple drug administrations and reduce animal brain damage caused by multiple surgeries.

As of 2024.04, RWD drug delivery cannula has facilitated the publication of 500+ papers.

Paper 1

Application Scenario

Pre-implanted drug delivery cannula (Figure a – cannula) in specific brain areas to facilitate local imaging using a GRIN lens and local drug administration.The drugs were continuously infused with a size-matched injector (0.41 mm outer diameter, RWD, 62201) at a rate of 0.1 µl min–1 through pump system.Drugs were locally infused into the brain over 10 min through an infusion cannula implanted immediately next to the guide cannula. Animals were subjected to enforced locomotion before and 20 min after local infusion. The effect of the locally infused drug was then determined by comparing locomotion-induced PKA activity between the two different conditions.

Paper 2

Application Scenario

Pre- implanted drug delivery cannula (Figure d) in mice bilateral LHb brain regions. One microlitre of the drug was infused (0.1 μl per 2.5 min) into each side through another set of tip-sharpened double injector cannulae, which were connected to the microsyringe. The injector cannulae were left in place for an additional 5 min to minimize the spread of the drug along the injection track. Behavioural tests were performed 1 h or 24 h after memantine infusion and 24 h, 7 days or 14 days after ketamine infusion.

Harnessing the dynamic equilibrium of ketamine–NMDAR interactions by activating the LHb and opening local NMDARs at different plasma ketamine concentrations, we were able to either shorten or prolong the antidepressant effects of ketamine in vivo.

Paper 3

Application Scenario

Pre-implanted drug delivery cannulas in different brain regions of ABX hM4Di and mCherry mice. Drug delivery cannulas were implanted into the PVN brain region to deliver VEH or CRF, and mice’s nonsocial activities were compared. Injection of VEH, CORT or DEX into the DG and BNST brain regions (Fig r – s).

Via microbiome profiling and in vivo selection, we identify a bacterial species, Enterococcus faecalis, that promotes social activity and reduces corticosterone levels in mice following social stress.

Paper 4

Application Scenario

Drug delivery cannulas were implanted into the bilateral hippocampal CA1 region, and rabbit anti-B2M antibody(Fig A)or control was injected once a week for 4 weeks. Five days after the last injection, the mice were subjected to behavioral tests and electrophysiological studies.

Research identify B2M as an endogenous NMDAR antagonist and reveal a pathophysiological role for circulating B2M in NMDAR dysfunction in Down syndrome and related cognitive disorders.

Paper 5

Application Scenario

Drug delivery cannulas were implanted into the primary auditory cortex (A1) region, after implanted cannula guide and recovery, mice received bilateral 1 mL infusions of 10 mM muscimol or 20 mM bicuculline or 20 mM 6-cyano-7-nitro-quinoxaline-2,3-dione or 50 mM D-2-amino-5-phosphonopentanoate or saline. Infusions were made at a rate of 0.2 mL/min with a syringe pump (RWD), and the infusion cannula was left in place for an additional 5 min to permit drug diffusion.

Other types of long-term administration

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