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RFLSI Ⅲ Laser Speckle Contrast Imaging System
MCAO model assessment
blood flow imaging
MCAO model
Hind limb ischemia research
RFLSI Ⅲ Laser Speckle Contrast Imaging System
MCAO model assessment
blood flow imaging
MCAO model
Hind limb ischemia research

RFLSI Ⅲ Laser Speckle Imaging System

RFLSI III is a robust blood perfusion imaging system. Along with advanced software, it helps researchers real-time monitor and record blood perfusion of any exposed tissues or organs for microcirculation study, to visualize the quantified data directly, shorten the experiment time, and obtain outcomes easily.

The model is not available. Please find the new model RFLSI-ZW.

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RFLSI  is based on the LSCI (Laser Speckle Contrast Imaging) technology. With the advantages of its non-contact, high frame-rate, high spatial resolution, it can be used to observe and record blood perfusion of any exposed tissues or organs for microcirculation study.

This system is designed for pre-clinical microcirculation researches like ischemic stroke, lower limbs, mesentery, etc. Multi-Output includes blood perfusion images and videos (4.2 million pixels), quantified data for perfusion unit and vessel diameter.


  • Cerebral blood perfusion monitoring
  • MCAO model assessment
  • Cortical spreading depression observation
  • Hind-limb ischemia research
  • Skin burn/skin flap transplantation
  • Organ microcirculation observation

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Reliable Data Measurement

Stable laser output for reliable and consistent measurement over minutes, hours and days, accuracy up to 0.1 PU, easy to control variables.

Full-Frame HD Image & Video

High-definition camera (full-frame 2048x2048 resolution) helps you see the blood vessel endings and opens the world of microcirculation imaging.

High Frame Rate

A high-speed camera (up to 120 FPS) allows you to record rapid changes every second and record more details of blood vessel changes after treatment.

Quantified Visualization Data

Full-field monitoring, quantitative analysis. Multi-output includes vascular perfusion volume, vessel diameter, vessel angle, etc., also offline state analysis available.

Guaranteed to Run Smoothly

USB 3.0 compatible.Data acquisition and blood perfusion image with video generated rapidly without delay.

Easy Operation

Unique non-contact technology, no need for a special dark environment. Autofocus function, easy to use, get perfusion data and video in seconds.


Successful Cases

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Journal: Nature Communication

Use the laser speckle to observe changes in cerebral blood flow after lymphatic ablation, and quantitative analysis.
Explore whether meningeal lymphatics are involved in clearing extravasated erythrocytes in CSF after SAH.

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Journal: Diabetes

Use LSCI to real-time detect regional velocity and distribution of blood flow and perfused blood vessel of sciatic nerve and foot pads, and also analyze image to better evaluate the therapeutic effect of small molecule substances on diabetes.

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Journal: Shock

The main purpose of the UPR is to restore ER homeostasis, and promote cell survival. It has been well established that brain I/R insult caused by transient ischemic stroke or CA/resuscitation leads to ER stress and subsequent activation of the UPR. The previous study has demonstrated that the XBP1s/HBP/O-GlcNAc axis functions in the brain, and is activated after ischemic stroke or CA (6, 8). Here, the goal was to clarify the effect of this axis on functional outcome after CA in young and aged mice.

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Ready to Get Started?

We have done RFLSI Ⅲ online demo with more than 200 global customers and got exemplary feedback from them. Welcome to try our free virtual demo to learn how our RFLSI Ⅲ can help in advanced scientific research.

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Clients Say

Clinical & Experimental Epilepsy

“I couldn’t suggest further hardware features as I feel everything the user would need is there. The quality of the images is wonderful, The pixel resolution of the images is very impressive also. The user friendly software allows the user to control all aspects of both the operation of the machine but also the analysis of the results. The features available for data analysis, such as the ROI function and blood perfusion graph, allow for exciting results. .....”

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--Dr Samuel M Flaherty

The University of Manchester

Stroke & Vascular Function

“We can use the Laser Speckle Imaging System to observe the 5th branch of Mesentery.”


--Yi-Je (Jay) Chen, Ph. D.

丨Assistant Professor, UC Davis

Brain Injury

“The instrument is incredibly easy to use allowing high-resolution images that can be used to assessed cerebral blood perfusion and vessels diameter at a highly reproducible level. I found impressive the possibility to monitor in real-time the results of several ROIs using the perfusion graph function provided in the software."


--Dr. Federico Moro

Istituto di ricerche farmacologiche Mario Negri

Our Customer

If you are a researcher in neuroscience, dermatology or other fields, RFLSI Ⅲ can help you tell the results you need.


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